CYP1A2 inhibitor
- Inhibits CYP1A2
- CYP1A2 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Toxicity risk rises with narrow-index victims
- Inhibition often begins faster than induction
- Smoking is a major environmental modifier.
Interaction at a glance
- Inhibits CYP1A2
Magnitude / time course
- Inhibits CYP1A2
- CYP1A2 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Inhibition often begins faster than induction
Clinical consequence
- Toxicity risk rises with narrow-index victims
Mechanism
- Smoking is a major environmental modifier.
Self-check
- Key risk with CYP1A2 inhibitor?
Toxicity risk rises with narrow-index victims. - How does the onset of CYP1A2 inhibition often compare with induction?
Inhibition often begins faster.
Drugs in this interaction (9)
All interaction examples · Open CYP1A2 inhibitor in the interactive console ↗