CYP1A2 inhibitor
- Inhibits CYP1A2
- CYP1A2 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Toxicity risk rises with narrow-index victims
- Inhibition often begins faster than induction
- Smoking is a major environmental modifier.
Interaction at a glance
Magnitude / time course
- Inhibits CYP1A2
- CYP1A2 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Inhibition often begins faster than induction
Clinical consequence
- Toxicity risk rises with narrow-index victims
Mechanism
- Smoking is a major environmental modifier.
Self-check
- What is the main clinical risk of CYP1A2 inhibitor?
Toxicity risk rises with narrow-index victims.
- Which enzyme or transporter is central to the CYP1A2 inhibitor interaction?
CYP1A2.
Drugs in this interaction (9)
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