Colchicine + CYP3A/P-gp inhibitor
- Colchicine = CYP3A4 + P-gp victim
- Dual inhibitors can sharply raise exposure
- clarithromycin AUC ↑ ~3.4×
- Toxicity: GI → myopathy → marrow failure
- Avoid with renal/hepatic impairment
- Dose-reduce or avoid strong inhibitors
Interaction at a glance
- Dual inhibitors can sharply raise exposure
- clarithromycin AUC ↑ ~3.4×
- Dose-reduce or avoid strong inhibitors
Mechanism
- Colchicine = CYP3A4 + P-gp victim
Magnitude / time course
- Dual inhibitors can sharply raise exposure
- clarithromycin AUC ↑ ~3.4×
Clinical consequence
- Toxicity: GI → myopathy → marrow failure
Management
- Avoid with renal/hepatic impairment
- Dose-reduce or avoid strong inhibitors
Self-check
- Which clearance pathways make colchicine interaction-sensitive?
CYP3A4 and P-gp. - Key risk with Colchicine + CYP3A/P-gp inhibitor?
Toxicity: GI → myopathy → marrow failure. - How should Colchicine + CYP3A/P-gp inhibitor be managed?
Avoid with renal/hepatic impairment.
Drugs in this interaction (9)
All interaction examples · Open Colchicine + CYP3A/P-gp inhibitor in the interactive console ↗