Absorption (food ↑)
- Food increases drug bioavailability
- Mechanisms: bile, solubilization, slower transit
- Some drugs must be taken with a meal
- Meal fat/calorie content may determine magnitude
- Fasting can make exposure subtherapeutic
Interaction at a glance
- Food increases drug bioavailability
Mechanism
- Some drugs must be taken with a meal
- Meal fat/calorie content may determine magnitude
Magnitude / time course
- Fasting can make exposure subtherapeutic
Mechanism / modifiers
- Mechanisms: bile, solubilization, slower transit
Mechanism / exceptions
- Food increases drug bioavailability
Self-check
- Which meal characteristics may determine a food-related exposure increase?
Fat and calorie content. - What can fasting do to exposure for a food-dependent drug?
Make it subtherapeutic.
Drugs in this interaction (8)
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