Vasopressin receptor antagonists (vaptans)
- Block vasopressin receptors
- V2 blockade causes free-water excretion
- Tolvaptan: hyponatremia + ADPKD roles
- Conivaptan also blocks V1a
- Over-rapid sodium correction is dangerous
- Thirst/polyuria are expected effects
Class at a glance
- Block vasopressin receptors
Members / distinctions
- Tolvaptan: hyponatremia + ADPKD roles
Pharmacology
- V2 blockade causes free-water excretion
- Conivaptan also blocks V1a
Practical pearls
- Thirst/polyuria are expected effects
Other practical pearls
- Over-rapid sodium correction is dangerous
Self-check
- What is the main pharmacologic action of Vasopressin receptor antagonists (vaptans)?
Block vasopressin receptors.
Drugs in this class (2)
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