Proton pump inhibitors (PPIs)
- Most potent routine acid suppression
- GERD, ulcers, H. pylori, GI protection
- Take before a meal for most PPIs
- Similar efficacy; interaction profiles differ
- Omeprazole/esomeprazole inhibit CYP2C19
- Long-term use: reassess ongoing indication
- Abrupt stop can cause rebound acid symptoms
Class at a glance
- Most potent routine acid suppression
Practical pearls
- Similar efficacy; interaction profiles differ
Pharmacology
- Omeprazole/esomeprazole inhibit CYP2C19
Clinical role
- GERD, ulcers, H. pylori, GI protection
- Take before a meal for most PPIs
- Long-term use: reassess ongoing indication
Other practical pearls
- Abrupt stop can cause rebound acid symptoms
Self-check
- Which drug class provides the most potent routine acid suppression?
Proton pump inhibitors (PPIs). - What can abrupt PPI discontinuation cause?
Rebound acid symptoms.
Drugs in this class (6)
Proton pump inhibitors (PPIs) prescription history
Animated chart of estimated U.S. prescriptions per year, Acid-suppressing meds (1977–2026). PPI highlighted from 1989.
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