Oxazolidinones
- 50S inhibitors active against resistant gram+
- Linezolid/tedizolid cover MRSA + VRE
- Excellent oral bioavailability
- Linezolid inhibits MAO → interaction concerns
- Thrombocytopenia with longer exposure
- Neuropathy with prolonged linezolid use
- Reserve for appropriate resistant infections
Class at a glance
- 50S inhibitors active against resistant gram+
Pharmacology
- Linezolid inhibits MAO → interaction concerns
Clinical role
- Linezolid/tedizolid cover MRSA + VRE
- Excellent oral bioavailability
- Thrombocytopenia with longer exposure
- Neuropathy with prolonged linezolid use
Other clinical roles
- Reserve for appropriate resistant infections
Self-check
- What resistant bacteria are key targets of oxazolidinones?
MRSA and VRE.
- What interaction concern is notable with linezolid?
MAO inhibition.
Drugs in this class (2)
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