NK1 antagonists
- Block substance-P NK1 signaling
- Major role: chemotherapy nausea prevention
- Aprepitant/fosaprepitant/netupitant/rolapitant
- Best for delayed emesis in combinations
- CYP3A interactions vary substantially
- Aprepitant changes dexamethasone exposure
- Not generally stand-alone rescue drugs
Class at a glance
- Block substance-P NK1 signaling
Pharmacology
- CYP3A interactions vary substantially
Clinical role
- Major role: chemotherapy nausea prevention
- Aprepitant/fosaprepitant/netupitant/rolapitant
Members / distinctions
- Best for delayed emesis in combinations
- Aprepitant changes dexamethasone exposure
- Not generally stand-alone rescue drugs
Self-check
- What is the major clinical role of NK1 antagonists?
Chemotherapy nausea prevention.
- When are NK1 antagonists especially useful?
Delayed emesis in combination regimens.
Drugs in this class (3)
All drug classes · Open the interactive console ↗
