Neurokinin-3 receptor antagonists
- Block NK3 signaling in thermoregulatory pathways
- Fezolinetant: selective NK3 antagonist
- Elinzanetant: dual NK1/NK3 antagonist
- Nonhormonal treatment for menopausal VMS
- Useful when hormone therapy is unsuitable/undesired
- Hepatic monitoring differs by agent
Class at a glance
- Block NK3 signaling in thermoregulatory pathways
Pharmacology
- Fezolinetant: selective NK3 antagonist
- Elinzanetant: dual NK1/NK3 antagonist
Clinical role
- Nonhormonal treatment for menopausal VMS
- Useful when hormone therapy is unsuitable/undesired
Safety / monitoring
- Hepatic monitoring differs by agent
Self-check
- When are Neurokinin-3 receptor antagonists especially useful?
hormone therapy is unsuitable/undesired.
- What is the main pharmacologic action of Neurokinin-3 receptor antagonists?
Block NK3 signaling in thermoregulatory pathways.
Drugs in this class (2)
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