Lipid-lowering agents (bile acid sequestrants)
- Bind bile acids in gut → ↑ LDL clearance
- Cholestyramine/colesevelam are examples
- Lower LDL modestly; may raise triglycerides
- GI effects and pill/powder burden are common
- Bind many other drugs → separate dosing
- No systemic absorption
Class at a glance
- Bind bile acids in gut → ↑ LDL clearance
Practical pearls
- Cholestyramine/colesevelam are examples
Other practical pearls
- Bind many other drugs → separate dosing
Safety / monitoring
- Lower LDL modestly; may raise triglycerides
- GI effects and pill/powder burden are common
- No systemic absorption
Self-check
- What do Lipid-lowering agents (bile acid sequestrants) bind?
bile acids in gut → ↑ LDL clearance.
Drugs in this class (3)
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