Ergot antimigraine agents
- Older migraine drugs with mixed receptor actions
- Ergotamine/dihydroergotamine are prototypes
- Constrict cranial/systemic vessels
- More adverse effects than triptans/gepants
- Major CYP3A inhibitor interactions can be dangerous
- Avoid in vascular disease and pregnancy
Class at a glance
- Older migraine drugs with mixed receptor actions
Practical pearls
- Ergotamine/dihydroergotamine are prototypes
Pharmacology
- Major CYP3A inhibitor interactions can be dangerous
Other practical pearls
- Constrict cranial/systemic vessels
Safety / monitoring
- More adverse effects than triptans/gepants
- Avoid in vascular disease and pregnancy
Self-check
- When should Ergot antimigraine agents generally be avoided?
vascular disease and pregnancy.
- What is the main pharmacologic action of Ergot antimigraine agents?
Older migraine drugs with mixed receptor actions.
Drugs in this class (2)
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