CFTR modulators
- Improve defective CFTR protein function
- Therapy is mutation/genotype specific
- Potentiators improve channel opening
- Correctors improve folding/trafficking
- Combination therapy can transform CF outcomes
- CYP3A interactions are often important
Class at a glance
- Improve defective CFTR protein function
Pharmacology
- Potentiators improve channel opening
- CYP3A interactions are often important
Practical pearls
- Therapy is mutation/genotype specific
Members / distinctions
- Correctors improve folding/trafficking
- Combination therapy can transform CF outcomes
Self-check
- What do CFTR potentiators improve?
Channel opening. - What do CFTR correctors improve?
Folding and trafficking.
Drugs in this class (2)
All drug classes · Open CFTR modulators in the interactive console ↗