CFTR modulators
- Improve defective CFTR protein function
- Therapy is mutation/genotype specific
- Potentiators improve channel opening
- Correctors improve folding/trafficking
- Combination therapy can transform CF outcomes
- CYP3A interactions are often important
Class at a glance
- Improve defective CFTR protein function
Pharmacology
- Potentiators improve channel opening
- CYP3A interactions are often important
Practical pearls
- Therapy is mutation/genotype specific
Members / distinctions
- Correctors improve folding/trafficking
- Combination therapy can transform CF outcomes
Drugs in this class (2)
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