Cephalosporins (third-generation)
- Stronger Gram-negative coverage overall
- Ceftriaxone/cefotaxime: major systemic agents
- Ceftazidime adds Pseudomonas activity
- Some penetrate CSF well
- Gram-positive activity varies by agent
- Resistance mechanism matters more than generation
Class at a glance
- Stronger Gram-negative coverage overall
Pharmacology
- Gram-positive activity varies by agent
- Resistance mechanism matters more than generation
Members / distinctions
- Ceftriaxone/cefotaxime: major systemic agents
Other member distinctions
- Ceftazidime adds Pseudomonas activity
- Some penetrate CSF well
Self-check
- Which third-generation cephalosporin adds Pseudomonas activity?
Ceftazidime. - What matters more than cephalosporin generation when assessing resistance?
Resistance mechanism.
Drugs in this class (6)
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