Calcium channel blockers (CCBs, dihydropyridine)
- Predominantly arterial vasodilators
- Amlodipine/nifedipine are prototypes
- Strong BP/angina drugs; little AV-node block
- Edema, flushing + headache are common
- Reflex tachycardia varies by formulation
- Generally safer than non-DHP CCBs in HFrEF
Class at a glance
- Predominantly arterial vasodilators
Members / distinctions
- Amlodipine/nifedipine are prototypes
- Reflex tachycardia varies by formulation
Pharmacology
- Strong BP/angina drugs; little AV-node block
Clinical role
- Generally safer than non-DHP CCBs in HFrEF
Practical pearls
- Edema, flushing + headache are common
Self-check
- What common adverse effects occur with DHP CCBs?
Edema, flushing, and headache. - How much AV-node block do DHP CCBs provide?
Little.
Drugs in this class (8)
Calcium channel blockers (CCBs, dihydropyridine) prescription history
Animated chart of estimated U.S. prescriptions per year, Calcium-channel blockers (1981–2026).
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