Barbiturates
- GABA-A positive modulators; high toxicity
- Phenobarbital: seizures + alcohol withdrawal
- Thiopental/methohexital: anesthesia niches
- Strong sedation + respiratory depression
- Tolerance, dependence + dangerous withdrawal
- Many induce hepatic enzymes
- Largely displaced by safer sedatives
Class at a glance
- GABA-A positive modulators; high toxicity
Members / distinctions
- Thiopental/methohexital: anesthesia niches
Safety / monitoring
- Phenobarbital: seizures + alcohol withdrawal
- Strong sedation + respiratory depression
Safety distinctions
- Tolerance, dependence + dangerous withdrawal
- Many induce hepatic enzymes
- Largely displaced by safer sedatives
Drugs in this class (6)
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