Antivirals (HIV protease inhibitors)
- Block viral polyprotein processing
- Darunavir is the dominant modern PI
- Often boosted with ritonavir/cobicistat
- High resistance barrier is clinically useful
- Major CYP3A interaction burden
- Metabolic/GI adverse effects are common
- Useful in selected resistant-treatment settings
Class at a glance
- Block viral polyprotein processing
Practical pearls
- Darunavir is the dominant modern PI
Pharmacology
- Major CYP3A interaction burden
Clinical role
- Often boosted with ritonavir/cobicistat
- High resistance barrier is clinically useful
- Useful in selected resistant-treatment settings
Safety / monitoring
- Metabolic/GI adverse effects are common
Self-check
- What is the main pharmacologic action of Antivirals (HIV protease inhibitors)?
Block viral polyprotein processing.
Drugs in this class (7)
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