Antivirals (HIV NRTIs / NtRTIs)
- Nucleos(t)ide reverse-transcriptase inhibitors
- Usually provide the 2-drug ART backbone
- TAF/TDF + FTC/3TC are common
- Tenofovir is also active against HBV
- TDF: renal/bone burden; TAF: more lipid/weight
- Abacavir requires HLA-B*57:01 screening
- Resistance history affects backbone choice
Class at a glance
- Nucleos(t)ide reverse-transcriptase inhibitors
Members / distinctions
- TDF: renal/bone burden; TAF: more lipid/weight
Practical pearls
- Usually provide the 2-drug ART backbone
- TAF/TDF + FTC/3TC are common
Other member distinctions
- Tenofovir is also active against HBV
- Abacavir requires HLA-B*57:01 screening
- Resistance history affects backbone choice
Drugs in this class (5)
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