Antivirals (HIV integrase inhibitors)
- Block viral DNA integration
- Foundation of most initial HIV regimens
- Bictegravir/dolutegravir are preferred anchors
- Rapid, potent + high resistance barrier
- Polyvalent cations can reduce absorption
- Weight gain occurs in some patients
- Cabotegravir enables long-acting treatment/PrEP
Class at a glance
- Block viral DNA integration
Members / distinctions
- Foundation of most initial HIV regimens
- Bictegravir/dolutegravir are preferred anchors
Clinical role
- Rapid, potent + high resistance barrier
- Polyvalent cations can reduce absorption
- Cabotegravir enables long-acting treatment/PrEP
Practical pearls
- Weight gain occurs in some patients
Self-check
- What is the main pharmacologic action of Antivirals (HIV integrase inhibitors)?
Block viral DNA integration.
Drugs in this class (5)
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