Antivirals (HIV integrase inhibitors)
- Block viral DNA integration
- Foundation of most initial HIV regimens
- Bictegravir/dolutegravir are preferred anchors
- Rapid, potent + high resistance barrier
- Polyvalent cations can reduce absorption
- Weight gain occurs in some patients
- Cabotegravir enables long-acting treatment/PrEP
Class at a glance
- Block viral DNA integration
Members / distinctions
- Foundation of most initial HIV regimens
- Bictegravir/dolutegravir are preferred anchors
Clinical role
- Rapid, potent + high resistance barrier
- Polyvalent cations can reduce absorption
- Cabotegravir enables long-acting treatment/PrEP
Practical pearls
- Weight gain occurs in some patients
Self-check
- How does Antivirals (HIV integrase inhibitors) work?
Block viral DNA integration. - What can reduce HIV integrase-inhibitor absorption?
Polyvalent cations.
Drugs in this class (5)
Antivirals (HIV integrase inhibitors) prescription history
Animated chart of estimated U.S. prescriptions per year, HIV antiretrovirals (1987–2026). Integrase inhibitors highlighted from 2008.
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