Antimuscarinics (overactive bladder)
- Reduce detrusor muscarinic signaling
- Urgency/frequency/urge incontinence
- Oxybutynin has high antimuscarinic burden
- Trospium has low CNS penetration
- Dry mouth + constipation limit adherence
- Retention/cognitive effects matter in older adults
- Beta-3 agonist is a non-antimuscarinic alternative
Class at a glance
- Reduce detrusor muscarinic signaling
Practical pearls
- Retention/cognitive effects matter in older adults
Alternative strategy
- Beta-3 agonist is a non-antimuscarinic alternative
Clinical profile
- Urgency/frequency/urge incontinence
- Oxybutynin has high antimuscarinic burden
- Trospium has low CNS penetration
Tolerability
- Dry mouth + constipation limit adherence
Self-check
- What clinically distinguishes Trospium within Antimuscarinics (overactive bladder)?
low CNS penetration.
- What clinically distinguishes Oxybutynin within Antimuscarinics (overactive bladder)?
high antimuscarinic burden.
Drugs in this class (7)
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