Antimuscarinics (overactive bladder)
- Reduce detrusor muscarinic signaling
- Urgency/frequency/urge incontinence
- Oxybutynin has high antimuscarinic burden
- Trospium has low CNS penetration
- Dry mouth + constipation limit adherence
- Retention/cognitive effects matter in older adults
- Beta-3 agonist is a non-antimuscarinic alternative
Class at a glance
- Reduce detrusor muscarinic signaling
Practical pearls
- Retention/cognitive effects matter in older adults
Alternative strategy
- Beta-3 agonist is a non-antimuscarinic alternative
Clinical profile
- Urgency/frequency/urge incontinence
- Oxybutynin has high antimuscarinic burden
- Trospium has low CNS penetration
Tolerability
- Dry mouth + constipation limit adherence
Self-check
- What distinguishes Trospium?
Low CNS penetration. - What distinguishes Oxybutynin?
High antimuscarinic burden.
Drugs in this class (6)
Antimuscarinics (overactive bladder) prescription history
Animated chart of estimated U.S. prescriptions per year, Overactive bladder meds (1970–2026).
All drug classes · Open Antimuscarinics (overactive bladder) in the interactive console ↗