Antidepressants (tetracyclic)
- Structural class, not one mechanism
- Mirtazapine is the main modern example
- Maprotiline is older and more toxic
- Often sedating; weight gain can be prominent
- Do not infer SRI activity from the name
- Seizure/cardiac risk differs by agent
Class at a glance
- Structural class, not one mechanism
Practical pearls
- Mirtazapine is the main modern example
Other practical pearls
- Maprotiline is older and more toxic
- Do not infer SRI activity from the name
Safety / monitoring
- Often sedating; weight gain can be prominent
- Seizure/cardiac risk differs by agent
Self-check
- Key risk with Antidepressants (tetracyclic)?
Seizure/cardiac risk differs by agent. - Which tetracyclic antidepressant is the main modern example?
Mirtazapine.
Drugs in this class (4)
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