Antidepressants (TCAs)
- Older broad monoamine-reuptake inhibitors
- Depression: usually later-line now
- Useful niches: pain, migraine, sleep, OCD
- clomipramine: potent SRI; OCD
- nortriptyline: cleaner TCA option
- Antimuscarinic + orthostasis + weight gain
- QRS widening + dangerous overdose toxicity
Class at a glance
- Older broad monoamine-reuptake inhibitors
Members / distinctions
- Depression: usually later-line now
Clinical role
- Useful niches: pain, migraine, sleep, OCD
- clomipramine: potent SRI; OCD
- nortriptyline: cleaner TCA option
Safety / monitoring
- Antimuscarinic + orthostasis + weight gain
- QRS widening + dangerous overdose toxicity
Self-check
- What useful nondepression niches do TCAs have?
Pain, migraine, sleep, and OCD.
- What cardiac toxicity makes TCA overdose dangerous?
QRS widening.
Drugs in this class (12)
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