Antidepressants (NDRIs)
- Norepinephrine/dopamine reuptake inhibition
- Bupropion is the major clinical member
- MDD, seasonal depression, smoking cessation
- Low sexual dysfunction + little weight gain
- Activating: insomnia, tremor, anxiety possible
- Lowers seizure threshold dose-dependently
- Strong CYP2D6 inhibitor
Class at a glance
- Norepinephrine/dopamine reuptake inhibition
Members / distinctions
- Activating: insomnia, tremor, anxiety possible
Pharmacology
- Strong CYP2D6 inhibitor
Practical pearls
- Bupropion is the major clinical member
- MDD, seasonal depression, smoking cessation
Safety / monitoring
- Low sexual dysfunction + little weight gain
- Lowers seizure threshold dose-dependently
Self-check
- Which NDRI is the major clinical member?
Bupropion. - What activating adverse effects can NDRIs cause?
Insomnia, tremor, and anxiety.
Drugs in this class (2)
Antidepressants (NDRIs) prescription history
Animated chart of estimated U.S. prescriptions per year, Antidepressants (1957–2026). NDRI highlighted from 1989.
All drug classes · Open Antidepressants (NDRIs) in the interactive console ↗