Antidepressants (NDRIs)
- Norepinephrine/dopamine reuptake inhibition
- Bupropion is the major clinical member
- MDD, seasonal depression, smoking cessation
- Low sexual dysfunction + little weight gain
- Activating: insomnia, tremor, anxiety possible
- Lowers seizure threshold dose-dependently
- Strong CYP2D6 inhibitor
Class at a glance
- Norepinephrine/dopamine reuptake inhibition
Members / distinctions
- Activating: insomnia, tremor, anxiety possible
Pharmacology
Practical pearls
- Bupropion is the major clinical member
- MDD, seasonal depression, smoking cessation
Safety / monitoring
- Low sexual dysfunction + little weight gain
- Lowers seizure threshold dose-dependently
Self-check
- Which NDRI is the major clinical member?
Bupropion.
- What activating adverse effects can NDRIs cause?
Insomnia, tremor, and anxiety.
Drugs in this class (2)
All drug classes · Open the interactive console ↗
