Antibacterials (folate-pathway)
- Block bacterial folate synthesis/utilization
- TMP + sulfonamide gives sequential blockade
- TMP-SMX is the classic combination
- Uses include UTI, MRSA skin + PJP
- Hyperkalemia + marrow toxicity can occur
- Important warfarin and renal interactions
Class at a glance
- Block bacterial folate synthesis/utilization
Pharmacology
- TMP + sulfonamide gives sequential blockade
Clinical role
- TMP-SMX is the classic combination
- Uses include UTI, MRSA skin + PJP
Safety / monitoring
- Hyperkalemia + marrow toxicity can occur
- Important warfarin and renal interactions
Self-check
- What is the advantage of TMP plus a sulfonamide?
Sequential folate-pathway blockade. - Key risk with Antibacterials (folate-pathway)?
Hyperkalemia + marrow toxicity can occur.
Drugs in this class (2)
Antibacterials (folate-pathway) prescription history
Animated chart of estimated U.S. prescriptions per year, Antibacterials (systemic) (1938–2026). Folate inhibitors highlighted from 1941.
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