Antiarrhythmics (Vaughan-Williams III)
- Predominantly prolong cardiac repolarization
- Usually via K+ channel blockade
- Includes sotalol, dofetilide, amiodarone
- QT/torsades risk varies greatly
- Amiodarone has many noncardiac toxicities
- Used for atrial and/or ventricular rhythms
Class at a glance
- Predominantly prolong cardiac repolarization
Practical pearls
- Includes sotalol, dofetilide, amiodarone
Pharmacology
- Usually via K+ channel blockade
Clinical role
- Used for atrial and/or ventricular rhythms
Safety / monitoring
- QT/torsades risk varies greatly
- Amiodarone has many noncardiac toxicities
Self-check
- What are Antiarrhythmics (Vaughan-Williams III) used for?
Atrial and/or ventricular rhythms. - What distinguishes Amiodarone?
Many noncardiac toxicities.
Drugs in this class (5)
Antiarrhythmics (Vaughan-Williams III) prescription history
Animated chart of estimated U.S. prescriptions per year, Antiarrhythmics (class I/III) (1930–2026). Class III highlighted from 1985.
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