5-HT4 prokinetics
- Stimulate enteric 5-HT4 receptors
- ↑ acetylcholine → ↑ GI motility
- Main niche: chronic constipation
- Prucalopride is the key modern agent
- Little antiemetic effect vs 5-HT3 drugs
- Older agents had more cardiac liability
Class at a glance
- Stimulate enteric 5-HT4 receptors
- ↑ acetylcholine → ↑ GI motility
Members / distinctions
- Prucalopride is the key modern agent
Comparison / safety
- Little antiemetic effect vs 5-HT3 drugs
- Older agents had more cardiac liability
Clinical use
- Main niche: chronic constipation
Self-check
- Which 5-HT4 prokinetic is the key modern agent?
Prucalopride. - What is the main clinical use of 5-HT4 prokinetics?
Chronic constipation.
Drugs in this class (3)
5-HT4 prokinetics prescription history
Animated chart of estimated U.S. prescriptions per year, Constipation meds (1900–2026). 5-HT4 agonists highlighted from 2002.
All drug classes · Open 5-HT4 prokinetics in the interactive console ↗