5-HT3 antagonists (setrons)
- Potent antiemetics; little sedation
- Main uses: CINV, PONV, acute nausea
- ondansetron/granisetron common
- palonosetron has very long action
- Constipation + headache are common
- QT effect varies; ondansetron is notable
- Do not confuse with serotonin toxicity drugs
Class at a glance
- Potent antiemetics; little sedation
Safety / monitoring
- QT effect varies; ondansetron is notable
Clinical role
- Main uses: CINV, PONV, acute nausea
- ondansetron/granisetron common
- palonosetron has very long action
Safety distinctions
- Constipation + headache are common
- Do not confuse with serotonin toxicity drugs
Self-check
- What are the main uses of 5-HT3 antagonists?
CINV, PONV, and acute nausea. - What common adverse effects occur with 5-HT3 antagonists?
Constipation and headache.
Drugs in this class (5)
5-HT3 antagonists (setrons) prescription history
Animated chart of estimated U.S. prescriptions per year, Antiemetics (1946–2026). 5-HT3 antagonists highlighted from 1991.
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