Tumor lysis syndrome (TLS) — prevention
- Risk-stratify before highly effective cancer therapy
- Aggressive hydration is foundational
- Allopurinol prevents new uric-acid formation
- Rasburicase rapidly removes uric acid in high-risk disease
- Monitor K, phosphate, Ca, uric acid + creatinine closely
- Treat established TLS as an oncologic emergency
Use at a glance
- Risk-stratify before highly effective cancer therapy
Practical pearls
- Aggressive hydration is foundational
Other practical pearls
- Allopurinol prevents new uric-acid formation
- Treat established TLS as an oncologic emergency
Monitoring / follow-up
- Rasburicase rapidly removes uric acid in high-risk disease
- Monitor K, phosphate, Ca, uric acid + creatinine closely
Self-check
- What should be treated in Tumor lysis syndrome (TLS) — prevention?
established TLS as an oncologic emergency.
- What should be risk-stratified in Tumor lysis syndrome (TLS) — prevention?
before highly effective cancer therapy.
Drugs used for this (2)
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