Tuberous sclerosis complex (TSC) — seizures
- Vigabatrin is first-line for TSC infantile spasms
- Other focal/generalized ASMs follow seizure phenotype
- Everolimus can reduce refractory TSC-associated seizures
- Ketogenic diet/surgery/VNS may be considered
- Early aggressive seizure control supports development
- Manage renal/brain/skin TSC manifestations in parallel
Use at a glance
- Vigabatrin is first-line for TSC infantile spasms
Escalation / refractory disease
- Everolimus can reduce refractory TSC-associated seizures
- Ketogenic diet/surgery/VNS may be considered
Practical pearls
- Manage renal/brain/skin TSC manifestations in parallel
Monitoring / follow-up
- Other focal/generalized ASMs follow seizure phenotype
- Early aggressive seizure control supports development
Self-check
- What is first-line treatment for Tuberous sclerosis complex (TSC) — seizures?
Vigabatrin.
Drugs used for this (1)
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