Syphilis
- Penicillin G is preferred at every stage
- Regimen depends on early vs late disease
- Neurosyphilis/ocular disease → IV penicillin
- Pregnancy requires penicillin even if allergic
- desensitize if needed
- Follow quantitative nontreponemal titers
- Evaluate/treat partners + test for HIV
Use at a glance
- Penicillin G is preferred at every stage
Practical pearls
- Neurosyphilis/ocular disease → IV penicillin
- Evaluate/treat partners + test for HIV
Choosing treatment
- Regimen depends on early vs late disease
- Pregnancy requires penicillin even if allergic
- desensitize if needed
Monitoring / follow-up
- Follow quantitative nontreponemal titers
Self-check
- What does syphilis in pregnancy require, even with allergy?
Penicillin. - What titers track syphilis treatment?
Quantitative nontreponemal titers.
Drugs used for this (2)
All clinical uses · Open Syphilis in the interactive console ↗