Sickle cell disease (SCD)
- Hydroxyurea reduces vaso-occlusive events
- Vaccination + infection prevention are essential
- Acute pain needs rapid multimodal analgesia
- Acute chest/stroke may require transfusion/exchange
- Disease-modifying options now extend beyond hydroxyurea
- Curative transplant/gene therapy applies to selected patients
Use at a glance
- Hydroxyurea reduces vaso-occlusive events
Practical pearls
- Acute pain needs rapid multimodal analgesia
- Acute chest/stroke may require transfusion/exchange
Other practical pearls
- Vaccination + infection prevention are essential
Escalation / refractory disease
- Disease-modifying options now extend beyond hydroxyurea
- Curative transplant/gene therapy applies to selected patients
Self-check
- What is needed for acute sickle-cell pain?
Rapid multimodal analgesia.
- What may acute chest syndrome or stroke require?
Transfusion or exchange transfusion.
Drugs used for this (1)
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