Serotonin toxicity / serotonin syndrome
- Stop serotonergic offending drugs
- Support airway, fluids + active cooling
- Benzodiazepines reduce agitation/muscle activity
- Severe hyperthermia → paralysis/intubation
- Cyproheptadine is an oral adjunct in selected cases
- Avoid antipyretics—heat is muscular, not hypothalamic
Use at a glance
- Stop serotonergic offending drugs
Treatment options
- Benzodiazepines reduce agitation/muscle activity
Choosing treatment
- Severe hyperthermia → paralysis/intubation
- Cyproheptadine is an oral adjunct in selected cases
Safety / pitfalls
- Support airway, fluids + active cooling
- Avoid antipyretics—heat is muscular, not hypothalamic
Self-check
- Which drugs are stopped in serotonin toxicity?
Offending serotonergic drugs. - Why avoid antipyretics in serotonin toxicity?
Heat is muscular, not hypothalamic.
Drugs used for this (1)
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