Primary biliary cholangitis (PBC)
- Ursodiol is first-line for nearly all patients
- Reassess biochemical response after ~1 year
- Inadequate response → add/switch 2nd-line drug
- seladelpar or elafibranor options
- Manage pruritus + bone disease separately
- Advanced disease → transplant evaluation
- Avoid obsolete withdrawn obeticholic-acid use
Use at a glance
- Ursodiol is first-line for nearly all patients
Escalation / refractory disease
- Inadequate response → add/switch 2nd-line drug
- seladelpar or elafibranor options
- Advanced disease → transplant evaluation
Practical pearls
- Manage pruritus + bone disease separately
Monitoring / follow-up
- Reassess biochemical response after ~1 year
- Avoid obsolete withdrawn obeticholic-acid use
Self-check
- What is first-line for nearly all PBC patients?
Ursodiol. - Which withdrawn PBC therapy should be avoided?
Obeticholic acid.
Drugs used for this (3)
All clinical uses · Open Primary biliary cholangitis (PBC) in the interactive console ↗