Primary biliary cholangitis (PBC)
- Ursodiol is first-line for nearly all patients
- Reassess biochemical response after ~1 year
- Inadequate response → add/switch 2nd-line drug
- seladelpar or elafibranor options
- Manage pruritus + bone disease separately
- Advanced disease → transplant evaluation
- Avoid obsolete withdrawn obeticholic-acid use
Use at a glance
- Ursodiol is first-line for nearly all patients
Escalation / refractory disease
- Inadequate response → add/switch 2nd-line drug
- seladelpar or elafibranor options
- Advanced disease → transplant evaluation
Practical pearls
- Manage pruritus + bone disease separately
Monitoring / follow-up
- Reassess biochemical response after ~1 year
- Avoid obsolete withdrawn obeticholic-acid use
Self-check
- What is first-line treatment for Primary biliary cholangitis (PBC)?
Ursodiol.
- What should generally be avoided in Primary biliary cholangitis (PBC)?
obsolete withdrawn obeticholic-acid use.
Drugs used for this (2)
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