Parkinson disease — dyskinesia
- Reduce levodopa peaks while preserving “on” time
- Smaller/more frequent dosing can help
- Amantadine is the principal antidyskinetic drug
- Extended-release amantadine can reduce troublesome dyskinesia
- DBS may help advanced medication-responsive disease
- Distinguish dyskinesia from tremor or “off” dystonia
Use at a glance
- Reduce levodopa peaks while preserving “on” time
Treatment options
- Smaller/more frequent dosing can help
- Amantadine is the principal antidyskinetic drug
Practical pearls
- Extended-release amantadine can reduce troublesome dyskinesia
Other practical pearls
- DBS may help advanced medication-responsive disease
- Distinguish dyskinesia from tremor or “off” dystonia
Self-check
- How should levodopa exposure change for dyskinesia?
Reduce levodopa peaks while preserving “on” time. - What is the principal antidyskinetic drug in Parkinson disease?
Amantadine.
Drugs used for this (2)
All clinical uses · Open Parkinson disease — dyskinesia in the interactive console ↗