Obstructive sleep apnea (OSA) — excessive daytime sleepiness
- Optimize OSA treatment first
- PAP adherence, sleep time, weight + other causes
- Persistent sleepiness → wake-promoting medication
- Modafinil/armodafinil or solriamfetol are options
- Pitolisant may be used where approved/appropriate
- Drug does not replace airway treatment
Use at a glance
- Optimize OSA treatment first
- PAP adherence, sleep time, weight + other causes
Practical pearls
- Persistent sleepiness → wake-promoting medication
Other practical pearls
- Modafinil/armodafinil or solriamfetol are options
Treatment options
- Pitolisant may be used where approved/appropriate
- Drug does not replace airway treatment
Self-check
- What comes first for persistent sleepiness in OSA?
Optimize OSA treatment.
- What can be added if sleepiness persists despite optimized OSA treatment?
A wake-promoting medication.
Drugs used for this (3)
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