Nephrogenic diabetes insipidus (lithium-induced)
- Lower lithium exposure if clinically feasible
- Amiloride is preferred pharmacologic treatment
- blocks lithium entry through ENaC
- Thiazide can reduce polyuria but raises lithium level
- Maintain free-water access
- Monitor sodium, kidney function + lithium level
Use at a glance
- Lower lithium exposure if clinically feasible
Treatment options
- Amiloride is preferred pharmacologic treatment
- blocks lithium entry through ENaC
Practical pearls
- Thiazide can reduce polyuria but raises lithium level
- Maintain free-water access
Monitoring / follow-up
- Monitor sodium, kidney function + lithium level
Self-check
- What is a key treatment approach for Nephrogenic diabetes insipidus (lithium-induced)?
Amiloride is preferred pharmacologic treatment.
- What should be monitored during treatment of Nephrogenic diabetes insipidus (lithium-induced)?
sodium, kidney function + lithium level.
Drugs used for this (1)
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