Nephrogenic diabetes insipidus (lithium-induced)
- Lower lithium exposure if clinically feasible
- Amiloride is preferred pharmacologic treatment
- blocks lithium entry through ENaC
- Thiazide can reduce polyuria but raises lithium level
- Maintain free-water access
- Monitor sodium, kidney function + lithium level
Use at a glance
- Lower lithium exposure if clinically feasible
Treatment options
- Amiloride is preferred pharmacologic treatment
- blocks lithium entry through ENaC
Practical pearls
- Thiazide can reduce polyuria but raises lithium level
- Maintain free-water access
Monitoring / follow-up
- Monitor sodium, kidney function + lithium level
Self-check
- What is the preferred pharmacologic treatment for lithium-induced nephrogenic DI?
Amiloride. - What is monitored in lithium-induced nephrogenic DI?
Sodium, kidney function + lithium level.
Drugs used for this (1)
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