Melanoma
- Surgery cures localized disease when feasible
- Stage III/IV treatment is mutation + immune-therapy driven
- PD-1–based immunotherapy is a major backbone
- BRAF V600 disease can use BRAF + MEK inhibitors
- Adjuvant systemic therapy lowers recurrence in high-risk disease
- Brain metastases may need combined local/systemic therapy
Use at a glance
- Surgery cures localized disease when feasible
Treatment options
- PD-1–based immunotherapy is a major backbone
Choosing treatment
- Stage III/IV treatment is mutation + immune-therapy driven
- BRAF V600 disease can use BRAF + MEK inhibitors
- Brain metastases may need combined local/systemic therapy
Other treatment options
- Adjuvant systemic therapy lowers recurrence in high-risk disease
Self-check
- What is a major melanoma treatment backbone?
PD-1–based immunotherapy. - Which melanoma mutation supports BRAF + MEK inhibitors?
BRAF V600.
Drugs used for this (3)
All clinical uses · Open Melanoma in the interactive console ↗