Huntington disease — chorea
- VMAT2 inhibitor is first-line pharmacologic treatment
- Deutetrabenazine/tetrabenazine reduce chorea
- Antipsychotic can help chorea + behavioral symptoms
- Treat depression, irritability + sleep separately
- Watch parkinsonism, sedation + depression
- Therapy reduces symptoms—not disease progression
Use at a glance
- VMAT2 inhibitor is first-line pharmacologic treatment
Treatment options
- Antipsychotic can help chorea + behavioral symptoms
Practical pearls
- Deutetrabenazine/tetrabenazine reduce chorea
- Treat depression, irritability + sleep separately
Other treatment options
- Watch parkinsonism, sedation + depression
- Therapy reduces symptoms—not disease progression
Self-check
- What should be treated in Huntington disease — chorea?
depression, irritability + sleep separately.
- What is first-line treatment for Huntington disease — chorea?
VMAT2 inhibitor.
Drugs used for this (3)
All clinical uses · Open the interactive console ↗
