Glioblastoma
- Maximal safe resection when feasible
- Radiation + temozolomide is standard backbone
- Continue adjuvant temozolomide after chemoradiation
- Tumor-treating fields can be added in selected patients
- MGMT methylation predicts temozolomide benefit
- Recurrence therapy is individualized; cure remains uncommon
Use at a glance
- Maximal safe resection when feasible
Practical pearls
- Radiation + temozolomide is standard backbone
Treatment options
- Continue adjuvant temozolomide after chemoradiation
- MGMT methylation predicts temozolomide benefit
- Recurrence therapy is individualized; cure remains uncommon
Choosing treatment
- Tumor-treating fields can be added in selected patients
Self-check
- What is the standard glioblastoma backbone?
Radiation + temozolomide. - What predicts temozolomide benefit in glioblastoma?
MGMT methylation.
Drugs used for this (2)
All clinical uses · Open Glioblastoma in the interactive console ↗