Geographic atrophy (GA) secondary to age-related macular degeneration (AMD)
- Complement inhibitors can slow GA lesion growth
- Pegcetacoplan/avacincaptad pegol are intravitreal options
- They slow progression; they do not restore lost vision
- Injection burden and neovascular-AMD risk matter
- Low-vision support remains important
- Treatment choice is individualized to lesion pattern/risk
Use at a glance
- Complement inhibitors can slow GA lesion growth
Practical pearls
- Pegcetacoplan/avacincaptad pegol are intravitreal options
Safety / pitfalls
- They slow progression; they do not restore lost vision
- Injection burden and neovascular-AMD risk matter
Treatment options
- Low-vision support remains important
- Treatment choice is individualized to lesion pattern/risk
Self-check
- What do complement inhibitors do in geographic atrophy?
Slow GA lesion growth.
- Do complement inhibitors restore vision already lost to geographic atrophy?
No.
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