Extrapyramidal symptoms (EPS)
- Identify the EPS phenotype first
- dystonia, akathisia, parkinsonism, TD
- Reduce/switch dopamine blocker when feasible
- Treatment differs by syndrome
- Antimuscarinics help dystonia/parkinsonism—not TD
- VMAT2 inhibitors treat tardive dyskinesia
Use at a glance
- Identify the EPS phenotype first
- dystonia, akathisia, parkinsonism, TD
Choosing treatment
- Reduce/switch dopamine blocker when feasible
Treatment options
- Treatment differs by syndrome
Practical pearls
- Antimuscarinics help dystonia/parkinsonism—not TD
- VMAT2 inhibitors treat tardive dyskinesia
Self-check
- Which drug class treats tardive dyskinesia?
VMAT2 inhibitors. - Which EPS phenotypes can antimuscarinics help?
Dystonia and parkinsonism—not tardive dyskinesia.
Drugs used for this (6)
All clinical uses · Open Extrapyramidal symptoms (EPS) in the interactive console ↗