Cytokine release syndrome (CRS)
- Grade severity + support airway/hemodynamics
- Tocilizumab is first-line for significant CAR-T–related CRS
- Corticosteroid for severe/refractory CRS
- Vasopressor/oxygen/ICU support as needed
- Distinguish CRS from sepsis and neurotoxicity
- Do not delay antimicrobials when infection remains plausible
Use at a glance
- Grade severity + support airway/hemodynamics
Treatment options
- Tocilizumab is first-line for significant CAR-T–related CRS
Escalation / refractory disease
- Corticosteroid for severe/refractory CRS
Safety / pitfalls
- Vasopressor/oxygen/ICU support as needed
- Distinguish CRS from sepsis and neurotoxicity
- Do not delay antimicrobials when infection remains plausible
Self-check
- What is first-line for significant CAR-T–related CRS?
Tocilizumab. - When is corticosteroid used for CRS?
Severe or refractory CRS.
Drugs used for this (1)
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