Clostridioides difficile infection (CDI)
- Stop unnecessary inciting antibiotic/PPI if possible
- Fidaxomicin preferred for many initial episodes
- Oral vancomycin remains effective alternative
- Fulminant CDI → high-dose oral/NG vancomycin
- Recurrent disease may need microbiota restoration
- Bezlotoxumab lowers recurrence in selected pts
- Avoid antiperistaltics in severe colitis
Use at a glance
- Stop unnecessary inciting antibiotic/PPI if possible
Practical pearls
- Fidaxomicin preferred for many initial episodes
Other practical pearls
- Oral vancomycin remains effective alternative
- Fulminant CDI → high-dose oral/NG vancomycin
- Recurrent disease may need microbiota restoration
Safety / pitfalls
- Bezlotoxumab lowers recurrence in selected pts
- Avoid antiperistaltics in severe colitis
Self-check
- Which inciting treatments should be stopped in CDI if possible?
Unnecessary antibiotics/PPIs. - Which drugs are avoided in severe CDI colitis?
Antiperistaltics in severe colitis.
Drugs used for this (1)
All clinical uses · Open Clostridioides difficile infection (CDI) in the interactive console ↗