CDKL5 deficiency disorder (CDD) — seizures
- Treat as severe developmental epileptic encephalopathy
- Ganaxolone is specifically approved for CDD seizures
- Other broad-spectrum ASMs are used by seizure phenotype
- Ketogenic diet/vagus stimulation may be considered
- Developmental/feeding/respiratory care is multidisciplinary
- Expect ongoing seizures despite polytherapy in many patients
Use at a glance
- Treat as severe developmental epileptic encephalopathy
Choosing treatment
- Ganaxolone is specifically approved for CDD seizures
- Other broad-spectrum ASMs are used by seizure phenotype
Practical pearls
- Ketogenic diet/vagus stimulation may be considered
Treatment options
- Developmental/feeding/respiratory care is multidisciplinary
- Expect ongoing seizures despite polytherapy in many patients
Self-check
- How should CDKL5 deficiency disorder (CDD) — seizures be treated?
As severe developmental epileptic encephalopathy.
Drugs used for this (1)
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