Anticoagulant reversal
- Reverse only when bleeding/urgent procedure warrants
- Warfarin: vitamin K + 4-factor PCC for major bleeding
- Dabigatran: idarucizumab
- Factor Xa inhibitors: andexanet or PCC strategy
- Heparin: protamine
- Restart anticoagulation once benefit again exceeds bleeding risk
Use at a glance
- Reverse only when bleeding/urgent procedure warrants
Practical pearls
Other practical pearls
- Factor Xa inhibitors: andexanet or PCC strategy
- Heparin: protamine
Treatment options
- Warfarin: vitamin K + 4-factor PCC for major bleeding
- Restart anticoagulation once benefit again exceeds bleeding risk
Self-check
- When should anticoagulation be reversed in Anticoagulant reversal?
bleeding/urgent procedure warrants.
Drugs used for this (4)
All clinical uses · Open the interactive console ↗
