Anticoagulant reversal
- Reverse only when bleeding/urgent procedure warrants
- Warfarin: vitamin K + 4-factor PCC for major bleeding
- Dabigatran: idarucizumab
- Factor Xa inhibitors: andexanet or PCC strategy
- Heparin: protamine
- Restart anticoagulation once benefit again exceeds bleeding risk
Use at a glance
- Reverse only when bleeding/urgent procedure warrants
Practical pearls
- Dabigatran: idarucizumab
Other practical pearls
- Factor Xa inhibitors: andexanet or PCC strategy
- Heparin: protamine
Treatment options
- Warfarin: vitamin K + 4-factor PCC for major bleeding
- Restart anticoagulation once benefit again exceeds bleeding risk
Self-check
- When is anticoagulation reversal warranted?
When bleeding or an urgent procedure warrants. - What reverses dabigatran?
Idarucizumab.
Drugs used for this (5)
All clinical uses · Open Anticoagulant reversal in the interactive console ↗