Anthracycline extravasation
- Stop infusion immediately; leave access for aspiration
- Dexrazoxane is the specific systemic antidote
- Start as soon as possible after doxorubicin-type extravasation
- Cold compress is used for anthracyclines
- Surgical review for evolving necrosis
- Do not flush drug further into tissue
Use at a glance
- Stop infusion immediately; leave access for aspiration
Practical pearls
- Dexrazoxane is the specific systemic antidote
- Start as soon as possible after doxorubicin-type extravasation
Other practical pearls
- Cold compress is used for anthracyclines
- Surgical review for evolving necrosis
Safety / pitfalls
- Do not flush drug further into tissue
Self-check
- What is the specific systemic antidote for anthracycline extravasation?
Dexrazoxane. - Should an anthracycline extravasation line be flushed?
No.
Drugs used for this (1)
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