Adrenocortical carcinoma
- Complete surgical resection is preferred when localized
- Mitotane is the key adrenolytic systemic drug
- Advanced disease may use mitotane + cytotoxic chemotherapy
- Control cortisol/androgen excess separately
- Mitotane has major PK interactions + adrenal toxicity
- Management is best at a specialty center
Use at a glance
- Complete surgical resection is preferred when localized
Treatment options
- Mitotane is the key adrenolytic systemic drug
- Control cortisol/androgen excess separately
Practical pearls
- Management is best at a specialty center
Other treatment options
- Advanced disease may use mitotane + cytotoxic chemotherapy
- Mitotane has major PK interactions + adrenal toxicity
Self-check
- When is complete surgical resection preferred for adrenocortical carcinoma?
When disease is localized. - What is the key systemic adrenolytic drug?
Mitotane.
Drugs used for this (1)
All clinical uses · Open Adrenocortical carcinoma in the interactive console ↗