Acute lymphoblastic leukemia (ALL)
- Multi-agent, phase-based chemotherapy is the backbone
- Regimen depends on age, lineage + genetics
- Add CNS prophylaxis
- Philadelphia-positive ALL → add BCR-ABL TKI
- Immunotherapy/CAR-T for selected relapsed disease
- Allogeneic transplant for selected high-risk/relapsed cases
Use at a glance
- Multi-agent, phase-based chemotherapy is the backbone
Practical pearls
- Add CNS prophylaxis
Choosing treatment
- Regimen depends on age, lineage + genetics
- Philadelphia-positive ALL → add BCR-ABL TKI
Escalation / refractory disease
- Immunotherapy/CAR-T for selected relapsed disease
- Allogeneic transplant for selected high-risk/relapsed cases
Self-check
- What is the ALL treatment backbone?
Multi-agent, phase-based chemotherapy. - What is added for Philadelphia-positive ALL?
Add BCR-ABL TKI.
Drugs used for this (1)
All clinical uses · Open Acute lymphoblastic leukemia (ALL) in the interactive console ↗