Pharmacogenomic topic · dashboard states: NM · PM · IM · UM
PGx describes inherited differences in drug handling. AUC measures total exposure, not benefit or toxicity by itself. Ask whether the pathway clears a drug or activates it: slower clearance can raise exposure; slower activation can reduce benefit. Lower inactive-metabolite exposure does not imply lost efficacy.
Dashboard vocabulary: NM = Normal metabolizer; PM = Poor metabolizer; IM = Intermediate metabolizer; UM = Ultrarapid metabolizer. RM = Rapid metabolizer appears only under CYP2C19; EXP = Expresser appears only under CYP3A5. These interface labels do not establish clinical phenotypes for every gene. Prescribing uses the laboratory report, current guidance and monitoring.