Precursor to metabolite: Venlafaxine to Desvenlafaxine
Venlafaxine is converted to Desvenlafaxine by CYP2D6.
The pair
- Venlafaxine — SNRI that is serotonergic at low doses, noradrenergic higher; short half-life, notable withdrawal.
- Desvenlafaxine — Active metabolite of venlafaxine; more balanced SNRI with simpler kinetics.
Anything that inhibits or induces CYP2D6 shifts the balance between Venlafaxine and Desvenlafaxine.
Venlafaxine · Desvenlafaxine · Open Venlafaxine in the interactive console ↗