Precursor to metabolite: Tenofovir alafenamide to Tenofovir
Tenofovir alafenamide is converted to Tenofovir by cathepsin A.
The pair
Tenofovir alafenamide — Cell-targeted tenofovir prodrug for HIV or hepatitis B; lower plasma tenofovir exposure generally reduces renal and bone toxicity versus TDF.
Tenofovir — Nucleotide reverse-transcriptase inhibitor; a backbone of HIV and PrEP therapy.