Precursor to metabolite: Tamoxifen to Endoxifen
Tamoxifen is converted to Endoxifen by CYP2D6.
The pair
- Tamoxifen — The classic breast-cancer SERM; a prodrug activated by CYP2D6.
- Endoxifen — Potent active tamoxifen metabolite made by CYP2D6; hence 2D6 inhibitors matter in breast cancer.
Anything that inhibits or induces CYP2D6 shifts the balance between Tamoxifen and Endoxifen.
Tamoxifen · Endoxifen · Open Tamoxifen in the interactive console ↗